Rare Anal Canal Cancer with Secondary Extramammary Paget’s Disease (Pagetoid Spread) Complicated by Squamous Cell Carcinoma of the Skin

Figure 4

Histological images. (a) Histological image of the vicinity of the pectinate line of the anal canal showing the invasion of adenocarcinoma with tube formation directly under the stratified squamous epithelium. It was mucinous. Pagetoid cells, which are large clear cells, diffused into the stratified squamous epithelium. (b) Histological image of the area between the pectinate line and the opening on the rectal mucous side. Pagetoid spread of atypical cells was observed in the rectal epithelium. (c) A histological image of the squamous cell carcinoma around the anus. The anal skin region partially continued to the hair follicles, and it was complicated with well-differentiated squamous cell carcinoma invading the dermis.

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