Rare Anal Canal Cancer with Secondary Extramammary Paget’s Disease (Pagetoid Spread) Complicated by Squamous Cell Carcinoma of the Skin

Figure 5

Immunohistochemical analysis of the resected adenocarcinoma around the anus. (a) Immunostaining for CK7. The adenocarcinoma directly under the squamous epithelium and atypical cells developing in the squamous epithelium was positive for CK7. (b) Immunostaining for CK19. The adenocarcinoma directly under the squamous epithelium and atypical cells developing in the squamous epithelium was positive for CK19. (c) Immunostaining for CK20. The adenocarcinoma directly under the squamous epithelium and atypical cells developing in the squamous epithelium was positive for CK20. (d) Immunostaining for CDX2. The adenocarcinoma directly under the squamous epithelium and atypical cells developing in the squamous epithelium was positive for CDX2. (e) Immunostaining of GCDFP15. The adenocarcinoma directly under the squamous epithelium and atypical cells developing in the squamous epithelium was negative for GCDFP15. (f) Immunostaining for MUC5A. The adenocarcinoma directly under the squamous epithelium was partially positive for MUC5A.

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