Extensively Invasive Gallbladder Cancer from Intracholecystic Papillary Neoplasm Treated with Pylorus-Preserving Pancreaticoduodenectomy and Extended Cholecystectomy: A Case Report and Literature Review

Table 1

Overview of the recent literature on ICPN.

Case	First author	Age (year)	Gender	Symptom	Imaging findings	Preoperative diagnosis	Surgical procedure	Invasive component	Lymph node metastasis	Adjuvant therapy	Outcome
1	Sato [8]	77	Female	Epigastric pain	Gallbladder tumor	Not mentioned	SC	Yes	No	No	Alive 10 months
2	Dettoni [9]	62	Female	Abdominal pain	Gallbladder tumor	Gallbladder cancer	EC	Yes	No	No	Alive 29 months
3	Meguro [10]	54	Female	Epigastric pain	Papillary tumor	Gallbladder tumor	EC, extrahepatic bile duct resection, and choledochojejunostomy	Yes (complicated with mixed adenoneuroendocrine carcinoma)	No	No	Alive 24 months
4	Hashimoto [4]	58	Female	Jaundice	Papillary tumor	Gallbladder cancer	EC, PD	Yes	No	No	Recurrence 16 months after surgery
5	Michalinos [11]	28	Female	Epigastric pain	Dilation of common bile duct	Choledochal cyst	SC, extrahepatic bile duct resection, and choledochojejunostomy	No	No	No	Not mentioned
6	Sato [12]	64	Male	Epigastric pain	Cystic tumor	Not mentioned	SC	Yes	No	No	Alive 8 months
7	Páez Cumpa [13]	39	Male	Epigastric pain	Gallbladder tumor	Not mentioned	SC	No	No	No	Alive 6 months
8	Unno [14]	74	Male	No	Papillary tumor	Gallbladder cancer	EC	Yes	No	No	Alive 3 months
9	Mizobuchi [15]	74	Female	No	Papillary tumor	Gallbladder cancer	EC	No	No	No	Not mentioned
10	Mizobuchi [15]	61	Female	No	Papillary tumor	Gallbladder cancer	EC	Not mentioned	No	No	Not mentioned
11	Mizobuchi [15]	83	Male	No	Papillary tumor	Not mentioned	EC	Not mentioned	No	No	Not mentioned
12	Sakai [5]	74	Male	Jaundice	Papillary tumor	Gallbladder cancer	EC, extrahepatic bile duct resection, and choledochojejunostomy	Yes	No	No	Not mentioned
13	Muranushi [16]	70	Male	No	Gallbladder tumor	Gallbladder cancer	EC	No	No	No	Alive 42 months
14	Hara [17]	71	Male	No	Papillary tumor	ICPN	SC	No	No	No	Not mentioned
15	Fujii [6]	59	Male	Fatigue	Papillary tumor	ICPN	SSPPD after SC	Yes	No	Tegafur/gimeracil/oteracil	Alive 2 months
16	Yokode [18]	58	Female	Fever	Papillary tumor	ICPN	EC and SSPPD	Yes	No	No	Alive 6 months
17	Sarıtaş [19]	52	Female	Right upper quadrant pain	Papillary tumor	Gallbladder tumor	SC	No	No	No	Not mentioned
18	Park [20]	78	Female	Epigastric pain	Gallbladder tumor	Not mentioned	SC	Yes (complicated with angiosarcoma)	No	No	Alive 3 months
19	Fraga [21]	85	Female	Epigastric pain	Gallbladder tumor	Not mentioned	EC	Yes (complicated with NEC)	No	No	Death 3 months; after surgery
20	Sciarra [22]	66	Female	Abdominal pain	Papillary tumor	Not mentioned	EC	Yes (complicated with MiNEN)	No	No	Alive 5 months
21	Oh [23]	79	Female	Abdominal pain	Papillary tumor	ICPN	SC	Yes	No	No	Alive 36 months
22	Iwasaki [24]	52	Female	No	Papillary tumor	Gallbladder cancer	EC, extrahepatic bile duct resection, and choledochojejunostomy	No	No	No	Alive 5 months
23	Oba [25]	78	Female	Jaundice and epigastric pain	Papillary tumor	Gallbladder tumor	SC	Yes	No	No	Alive 12 months
24	Logrado [26]	71	Female	Epigastric pain	Wall thickness of the gallbladder	Not mentioned	SC	No	No	No	Alive 30 months
25	Iseki [7]	83	Male	No	Papillary tumor	Distal bile duct cancer	SSPPD	Yes	N0	No	Alive 20 months
26	Kuniyoshi [27]	86	Female	Jaundice	Papillary tumor	ICPN	SC	No	No	No	Alive 12 months
27	Ismail [28]	48	Female	No	Gallbladder tumor	Gallbladder tumor	SC	No	No	No	Not mentioned
28	Aida [29]	65	Female	No	Papillary tumor	Gallbladder cancer	EC	No (complicated with xanthogranulomatous cholecystitis)	No	No	Alive 3 months
29	Dörr [30]	77	Female	No	Wall thickness of the gallbladder	Chronic cholecystitis	SC	Yes	No	No	Not mentioned
30	Shimada [31]	69	Male	No	Papillary tumor	Gallbladder cancer	EC	Yes	No	No	Alive 12 months
31	Wong [32]	49	Male	No	Gallbladder tumor	Not mentioned	SC	No	No	No	Not mentioned
32	Trisal [33]	48	Male	Epigastric pain	Wall thickness of the gallbladder	Not mentioned	SC	No (complicated with xanthogranulomatous cholecystitis)	No	No	Alive 6 months
33	Watanabe [34]	79	Female	No	Gallbladder tumor	Gallbladder cancer	EC after subtotal cholecystectomy	Yes	No	No	Alive 8 months
34	Oishi [35]	60s	Female	No	Papillary tumor	ICPN	EC and resection of the extrahepatic bile duct	No	No	No	Alive 24 months
35	Limaiem [36]	76	Male	Right upper quadrant pain	Papillary tumor	Not mentioned	EC	Yes	No	No	Not mentioned
36	Scarola [37]	80	Male	Fatigue	Gallbladder tumor	Not mentioned	EC	Yes	No	No	Alive 6 months
37	Mruthyunjayappa [38]	70s	Male	Right upper quadrant pain	Gallbladder tumor	Gallbladder cancer	EC	Yes (complicated with NEC)	No	No	Death 50 months after surgery
38	Koike [39]	44	Male	No	Gallbladder tumor	Cholesterol polyp or pyloric-type adenoma	SC	No	No	No	Not mentioned
39	Our case	75	Male	Jaundice	Papillary tumor	Distal bile duct cancer	PPPD and EC	Yes	Yes	Tegafur/gimeracil/oteracil	Alive 12 months
Summary		Age	Male	No symptom	Papillary tumor	ICPN	SC	Yes	Yes	Tegafur/gimeracil/oteracil	Follow-up duration,
		66.3	17	17 (43.6)	22 (56.4)	6 (15.4)	14 (35.9)	22	1	2	Months
		(28–86)	Female	Abdominal pain	Gallbladder tumor	Gallbladder cancer	EC	No	No	No	14.2 (2–50)
			22	16 (41.0)	12 (30.8)	13 (33.3)	21 (53.8)	17	38	37	Alive
				Jaundice	Wall thickness of the gallbladder	Gallbladder tumor	Resection of the extrahepatic bile duct				24
				5 (12.8)	3 (7.8)	4 (10.3)					Recurrence
							5 (12.8)				3
							PD				Death
							5 (12.8)				2

Data are expressed as the mean (range) or number (%).
ICPN: intracholecystic papillary neoplasm; SC: simple cholecystectomy; EC: extended cholecystectomy; PD: pancreaticoduodenectomy; SSPPD: subtotal stomach-preserving pancreaticoduodenectomy; PPPD: pylorus-preserving pancreaticoduodenectomy; NEC: neuroendocrine carcinoma; MiNEN: mixed neuroendocrine-non-neuroendocrine neoplasm.