Histomorphology and Immunohistochemistry of a Congenital Nephromegaly Demonstrate Concurrent Features of Heritable and Acquired Cystic Nephropathies in a Girgentana Goat (Capra falconeri)

Figure 1

Macroscopic and microscopic features of renal and hepatic tissue. Kidney (a–e): (a) severe diffuse perpendicular polycystic alteration of the renal parenchyma. The discrimination of cortex and medulla fails. Normal sized twin kidney for scale (upper left corner). (b, c) Polycystic alteration of the renal parenchyma (asterisk) is lined by a flattened epithelium. Multifocal polypoid proliferates/projections of the tubular epithelium can be seen (thin arrows). Furthermore, there are single morphologically matured glomeruli (arrowhead). The interstitial tissue is characterized by a delicate fibrovascular stroma, blood vessels, and numerous atrophic/necrotic tubules (thick arrow). Hematoxylin and eosin (HE) (d) polypoid proliferates/projections (arrow) consist of protruding round to ovoid cells, occasionally occurring with a foamy/vacuolated pale eosinophilic cytoplasm. HE (e) fibrous protrusion lined by isoprismatic epithelium is obvious. HE. Liver: (f) multifocal proliferated and dilated biliary ducts (asterisk), surrounded by marked pericholangiolar bridging fibrosis (green). Occasionally, supraepithelial granular structures can be seen (arrow). Numerous blood vessels occur with a marked perivascular fibrosis (inset). Masson’s Trichrome.

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