EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method

Figure 1

Relation between plasma EGFR mutations and duration of EGFR-TKIs treatment. (A): group of cases having no EGFR mutation in the plasma before TKI treatment (P0) and during TKI treatment (P1). (B): group of patients whose EGFR mutation status converted from positive at P0 to negative at P1. (C): group of patients with mutations both at P0 and at P1. Arrows indicate cases that are still under treatment. Asterisks show cases receiving combination of TKIs and chemotherapy.