The Value of Combined Radial Endobronchial Ultrasound-Guided Transbronchial Lung Biopsy and Metagenomic Next-Generation Sequencing for Peripheral Pulmonary Infectious Lesions
Table 1
Baseline characteristics of study population.
Groups
TBLB group
R-EBUS-TBLB group
t/χ2 value
value
Particients
60
61
Age ± 2SD (years)
55.8 ± 12.5
55.4 ± 11.5
1.168
0.243
Male/female
38/22
36/25
0.237
0.626
Immunodeficiency
Hematological malignancy
34 (56.7)
36 (59.0)
0.068
0.794
Lesion location n%
Lower lobe
27 (45.0)
33 (54.1)
2.524
0.283
Right upper lobe
16 (26.7)
18 (29.5)
Left upper lobe
17 (28.3)
10 (16.4)
Leision size
≤3 cm
19 (31.7)
18 (29.5)
0.066
0.797
>3 cm
41 (68.3)
43 (70.5)
Distance from the chest wall
≤3 cm
22 (36.7)
28 (45.9)
1.064
0.302
>3 cm
38 (63.3)
33 (54.1)
CT findings
Nodule or cavitation
19 (31.7)
28 (45.9)
2.720
0.257
Confluent or patchy consolidation
29 (48.3)
22 (36.1)
GGO
12 (20.0)
11 (18.0)
Complications
Mild bleeding
2 (3.3)
1 (1.6)
0.359
0.549
Pneumothorax
2 (3.3)
1 (1.6)
0.356
0.551
Final diagnosis
Bacteria (mycobacteria excluded)
30 (50)
33 (54.1)
Virus
12 (20)
11 (18)
Fungus
18 (30)
21 (34.4)
Atypical pathogen
6 (10)
7 (11.5)
MTBC
9 (15)
10 (16.4)
Positivity of mNGS
36 (60.0)
48 (78.7)
4.977
0.026
GGO, ground-glass opacity. MTBC, mycobacterium tuberculosis complex. Data are presented as no. (%) or mean ± SD unless otherwise indicated.
