The Value of Combined Radial Endobronchial Ultrasound-Guided Transbronchial Lung Biopsy and Metagenomic Next-Generation Sequencing for Peripheral Pulmonary Infectious Lesions

Table 2

The relationship between clinical and image characteristics of PPLs and the diagnostic yield of R-EBUS-guided TBLB detected infectious pathogens by mNGS.

Variables	mNGS diagnostic	mNGS nondiagnostic	Univariate	Multivariate
			OR value	OR value
Lesion size
>3 cm	38 (79.2)	5 (38.5)	6.080 0.013	8.757 0.067
≤3 cm	10 (20.1)	8 (61.5)
Distance from the chest wall
>3 cm	29 (60.4)	4 (30.8)	3.434 0.057
≤3 cm	19 (39.6)	9 (69.2)
R-EBUS probe position
Within	34 (70.8)	4 (30.8)	5.464 0.009	17.742 0.030
Adjacent to	14 (29.2)	9 (69.2)
Internal echoes
Homogeneity	35 (72.9)	4 (30.8)	6.058 0.005	8.598 0.061
Heterogeneity	13 (27.1)	9 (69.2)
Anechoic areas
Yes	5 (10.4)	8 (61.5)	13.760 < 0.001	17.878 0.019
No	43 (89.6)	5 (38.5)
Luminant areas
Yes	8 (16.7)	8 (61.5)	8 0.001	16.745 0.042
No	40 (83.3)	5 (38.5)
Total cases	48	13

PPLs, peripheral lung lesions. R-EBUS, radial endobronchial ultrasound. TBLB, transbronchial lung biopsy. mNGS, metagenomic next-generation sequencing. Data are presented as no. (%) unless otherwise indicated.