Research Article
Genetic Evolution of Mycobacterium abscessus Conferring Clarithromycin Resistance during Long-Term Antibiotic Therapy
Table 2
Microbiological characteristics of 6 paired M. abscessus isolates.
| | Variable | Patient 1 | Patient 2 | Patient 3 | | G142 | G179 | A38 | A243 | G139 | A317 |
| | AMI (amikacin) | >64 (R) | >64 (R) | 2 (S) | 8 (S) | 4 (S) | 8 (S) | | SXT (sulfonamides) | >8 (R) | >8 (R) | >8 (R) | >8 (R) | >8 (R) | >8 (R) | | MXF (moxifloxacin) | 8 (R) | 8 (R) | >8 (R) | >8 (R) | 8 (R) | 8 (R) | | FOX (cefoxitin) | 64 (I) | 128 (R) | 64 (I) | 128 (R) | 128 (R) | >128 (R) | | DOX (doxycycline) | >16 (R) | >16 (R) | >16 (R) | >16 (R) | 8 (R) | 16 (R) | | TGC (tigecycline) | 0.12 (S) | 0.12 (S) | 0.12 (S) | 0.5 (S) | 0.5 (S) | 4 (R) | | LZD (linezolid) | 4 (S) | 8 (S) | 16 (I) | 32 (R) | 16 (I) | 32 (R) | | IMI (imipenem) | 16 (I) | 16 (I) | 32 (R) | 64 (R) | 8 (I) | 64 (R) | | TOB (tobramycin) | >16 (R) | >16 (R) | 4 (I) | 8 (R) | 4 (I) | >16 (R) | | CLA (clarithromycin, D3) | 2 (S) | >64 (R) | 2 (S) | 64 (R) | 0.06 (S) | 16 (R) | | CLA (clarithromycin, D14) | 32 (R) | >64 (R) | 16 (R) | >64 (R) | 16 (R) | >64 (R) | | Genotype | A | A | A | A | C3042T | C3042T | | rrl mutation | None | None | None | None | None | None | | Morphotype | Rough | Rough | Rough | Rough | Rough | Rough |
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S: susceptible; I: intermediate; R: resistant; D3, MIC at day 3; D14, MIC at day 14.
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