Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage: Predictive Role for Acute Exacerbation of Idiopathic Interstitial Pneumonias

Table 3

Predictive factors of AE in IIPs (multivariate Cox proportional hazard regression analysis).

Parameters	HR	95% CI	value
mMRC, ≥2 vs. <2	3.345	1.690‒6.623	0.001
HS, ≥61.5 vs. <61.5	5.649	1.919‒16.624	0.002
IPF vs. Non-IPF	3.268	1.754‒6.098	< 0.001
%FVC	0.964	0.945‒0.984	0.001

Abbreviations: AE, acute exacerbation; CI, confidence interval; FVC, forced vital capacity; HR, hazard ratio; HS, hemosiderin score; IIPs, idiopathic interstitial pneumonias; IPF, idiopathic pulmonary fibrosis; mMRC, modified Medical Research Council Score for shortness of breath. Multivariate Cox proportional hazard regression analysis with a stepwise selection method using significant parameters shown in Table 2 was performed.