Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage: Predictive Role for Acute Exacerbation of Idiopathic Interstitial Pneumonias

Table 4

Predictive models of occurrence of AE-IIPs with/without hemosiderin score.

	Parameters	C-statistics	95% CI
Model 1:	IPF vs. Non-IPF mMRC, ≥2 vs. <2; %FVC	0.7702	0.6877‒0.8361
Model 2:	IPF vs. Non-IPF mMRC, ≥2 vs. <2; %FVC; HS, ≥61.5 vs. <61.5	0.7932	0.7170‒0.8531

Abbreviations: CI, confidence interval; FVC, forced vital capacity; HS, hemosiderin score; IPF, idiopathic pulmonary fibrosis; mMRC, modified Medical Research Council Score for shortness of breath. Difference in the C-statistics of the two models was not significant using DeLong’s method ( = 0.1539).