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| Reference (year of publication) | Design | Population studied | Country | Sample size (case/control) | Outcomes and method | Quality assessment |
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| Zein 2017 | Retrospective study | Vaccination: 32,900 (42.9%) individuals received the vaccine within their first year of life, 2,712 (3.5%) were vaccinated later. Follow up: children born at 32 weeks of gestation until 20n years Quebec, Canada, 1974. | Developed country | 893/750 | Asthma at least 2 asthma-related medical services or at least 1 asthma- related hospitalization (international classification of diseases, ninth revision, code 493) | B |
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| Alm 1997 | Retrospective study | Vaccination: Before the age of 6 months, follow up: children at 3–7 years Stockholm, Sweden 1991 | Developed country | 216/358 | Eczema, asthma, rhinitis atopic disease in history and/or at the clinical examination, as well as skin prick test and IgE in a blood sample | B |
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| Garcia 2005 | Retrospective study | Vaccination: When the children were born follow up: children aged 6 and 7 years old health centers in Spain | Developed country | 6762/2828 | Eczema, asthma, rhinitis the Spanish version of the ISAAC phase III questionnaire | B |
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| Gruber 2002 | Retrospective study | Vaccination: When the children were born follow up: children who were starting school (mean age 6 years) Germany, 1994 | Developed country | 20383/18425 | Eczema, asthma, rhinitis a mandatory health survey | B |
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| Marks 2003 | Retrospective study | Vaccination: In the first 8 weeks of life follow up: yellow race children aged 7 to 14 years old Sydney, Australia | Developed country | 309/442 | Eczema, asthma, rhinitis subjects underwent allergen SPTs, spirometry, a methacholine inhalation challenge test, a venous blood collection for IgE assay and lymphocyte studies, and a TST | B |
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| Miyake 2008 | Retrospective study | Vaccination: In infancy according to school records follow up: 8–11 years of age Japan | Developed country | 5567/150 | Eczema, asthma, rhinitis a self-administered questionnaires included questions on symptoms of wheeze, asthma, atopic eczema | B |
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| Linehan 2007 | Retrospective study | Vaccination: Before the age of 12 weeks followed up: 6–11 years of age health care center, England | Developed country | 1332/1076 | Wheeze a parent-completed questionnaire, based on the international study of asthma and allergies in childhood asthma questionnaire 12 with some additional questions | B |
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| da cunha 2004 | Cross-sectional | Vaccination: When the children were born followed up: children of 12–14 years Salvador, Brazil | Developing country | 1089/523 | Eczema, asthma, rhinitis based on self-reporting of current allergy and whether this was accompanied by sneezing and/or skin manifestations | C |
| Mommers 2004 | Nested case-control study | Vaccination: When the children were born followed up: children at 7–8 years of age Netherlands and Germany | Developed country | Case:75 | Asthma ISAAC questionnaire and questions on indoor environment, specific IgE was measured in the blood | C |
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| Mohrenschlager 2007 | Cross-sectional study | Vaccination: Unknow followed up: at 5–7 years (preschool) augsburg Germany | Developed country | 1219/247 | Eczema, asthma, rhinitis skin prick test reaction more than 2 mm | C |
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| Pahari 2002 | Cross-sectional study | Vaccination: Unknow follow up: children aged 11–18 years from secondary school England | Developed country | Case:308 | Asthma clinical symptom | C |
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| Thestesen 2018 | RCT | Vaccination: When the children were born follow up: from birth to 13 months of age Denmark | Developed country | 2052/1952 | Eczema the severity of AD was graded using SCORAD | B |
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| Gruber 2001 | Prospective study | Vaccination: Within their first weeks of life follow up: from birth to 7 years old Freiburg, Germany | Developed country | 92/682 | Eczema, asthma, rhinitis parents filled in a questionnaire and gave a structured interview about their children s diseases and atopic symptoms | B |
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| Soysal 2008 | Retrospective study | Vaccination: Unknow follow up: children with recent household contact to adult given a diagnosis of sputum smear– positive pulmonary TB at one of 7 government- funded TB clinics istanbul | Developing country | 290/71 | Eczema, asthma, rhinitis all children underwent TST and chest radiography, and gave 10-ml of venous blood sample for the RD1 ELISpot assay and total serum IgE level | B |
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| Steenhuis 2008 | RCT | Vaccination: When the children were born Follow up: high-risk newborns in the pediatric Utrecht, Netherlands | Developed country | 62/59 | Eczema, asthma rhinitis an adapted version of the british medical research council questionnaire and the Dutch version of the european community respiratory health survey were used | C |
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| Wickens 2001 | Case-control study | Vaccination: When the children were born follow up: children aged 6–7 and 13–14 from a random selection of schools Wellington, New Zealand | Developed country | 220/231 | Asthma the case-control study was based on the Wellington, New Zealand, arm of the ISAAC | C |
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| Peleteiro 2018 | RCT | Vaccination: All individuals had been vaccinated with BCG in early childhoodFollow up: healthy undergraduate studentsSalvador, Bahia, Brazil | Developing country | 46/29 | Eczema, asthma rhinitis sociodemographic and clinical characteristics were obtained using a standard questionnaire and the ISAAC questionnaire. Total serum IgE levels were measured | B |
| Park 2015 | Retrospective study | Vaccination: unknowFollow up: adults who underwent skin pricktesting, Korea | Developed country | 135/40 | Asthma the results from spirometry and bronchial provocation testing conducted within one month from the date of SPT | C |
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| Singh 2013 | Cross-sectional study | Vaccination: unknowFollow up: aged 7–14 years Chandigarh, North India. | Developing country | 7792/1700 | Eczema, asthma rhinitis symptoms were assessed according to the ISAAC phase II questionnaire that asked for infor- mation on demography, symptoms of wheeze, asthma, rhinitis, and eczema, together with various possible risk factors | B |
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| Thestesen 2017 | RCT | Vaccination: When the children were born follow up: newborns (3–13 months) Denmark | Developed country | 2100/2071 | Asthma at 3 and 13 months, the children were invited for a clinical examination at the study site, where study staff evaluated the child's breathing and made an auscultation | B |
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