The Therapeutic Effect of Traditional LiuJunZi Decoction on Ovalbumin-Induced Asthma in Balb/C Mice

Figure 6

LJZD reduced miR-21 and miR-146a expression and suppressed the activation of the NF-κB signaling pathway. Real-time PCR analysis of the miR-21 (a) and miR-146a (b) expression in lung tissues of the Con, Mod, DXM, and high-, medium-, and low-dosage LJZD groups. (c) The representative images of western blotting analysis of NF-κB, phospho (p)-NF-κB, IκBα, p-IκBα, and AP-1 expression in lung tissues of all the groups. The relative expression levels of p-NF-κB (d), p-IκBα (e), and AP-1 (f) are shown, and Actb was used as an internal control. Data were expressed as the mean ± SD (n = 3). NF-κB: nuclear factor kappa-B, IκBα: NF-κB inhibitor alpha, and AP-1: activating protein-1.

(a)

(b)

(c)

(d)

(e)

(f)