Inhibitory Effect of Paquinimod on a Murine Model of Neutrophilic Asthma Induced by Ovalbumin with Complete Freund’s Adjuvant

Figure 4

Western blot of inflammasomes, S100A9, and cytokines in mice lung lysates. (a) A representative figure of western blot of S100A9 (13 kDa), procaspase-1 (46 kDa), cleaved caspase-1 (30 kDa), p20 activated caspase-1 (20 kDa), precursor IL-1 β (31 kDa), mature form IL-1β (17 kDa), MPO (65 kDa), IL-17 (18 kDa), IFN-γ (17 kDa), and TNF-α (25 kDa) performed on the pooled lung lysates from sham-treated (n = 3), CFA/OVA-treated mice (n = 3), and CFA/OVA plus paquinimod (10 mg/kg/d, p.o.) (n = 3) (b) and their densitometry of the western blot band intensity normalized to that of β-actin.

(a)

(b)