Mitochondrial ATP-Sensitive K+ Channel Opening Increased the Airway Smooth Muscle Cell Proliferation by Activating the PI3K/AKT Signaling Pathway in a Rat Model of Asthma

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Group</td><td class="align_center"><i>N</i></td><td class="align_center">GAPDH-Ct (Ct-G)</td><td class="align_center">AKT-Ct (Ct-AKT)</td><td class="align_center">2<sup>−ΔΔCt</sup></td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Normal group</td><td class="align_center">9</td><td class="align_center">17.87 ± 0.64</td><td class="align_center">25.01 ± 0.60</td><td class="align_center">1.00</td></tr><tr><td class="align_left">Normal + diazoxide group</td><td class="align_center">9</td><td class="align_center">19.66 ± 0.27</td><td class="align_center">26.66 ± 0.16</td><td class="align_center">1.14 ± 0.26</td></tr><tr><td class="align_left">Normal + 5-HD group</td><td class="align_center">9</td><td class="align_center">19.32 ± 1.05</td><td class="align_center">27.26 ± 0.56</td><td class="align_center">0.98 ± 0.26</td></tr><tr><td class="align_left">Asthma group</td><td class="align_center">9</td><td class="align_center">18.36 ± 0.26</td><td class="align_center">25.49 ± 0.48</td><td class="align_center">0.97 ± 0.32</td></tr><tr><td class="align_left">Asthma + diazoxide group</td><td class="align_center">9</td><td class="align_center">15.10 ± 0.53</td><td class="align_center">22.11 ± 0.43</td><td class="align_center">1.12 ± 0.30</td></tr><tr><td class="align_left">Asthma + 5-HD group</td><td class="align_center">9</td><td class="align_center">16.66 ± 0.57</td><td class="align_center">23.66 ± 0.55</td><td class="align_center">1.13 ± 0.27</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>The mRNA expression levels of the AKT in ASMCs were determined by comparative Ct value, and the results were expressed as the mean ± SD.<br/></div></td></tr></table>

<div>The mRNA expression of protein kinase B (AKT) in airway smooth muscle cells (ASMCs) in the asthma rat model.</div>

Canadian Respiratory Journal

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Table 2

Table 2: Mitochondrial ATP-Sensitive K+ Channel Opening Increased the Airway Smooth Muscle Cell Proliferation by Activating the PI3K/AKT Signaling Pathway in a Rat Model of Asthma 

Table 2 | Mitochondrial ATP-Sensitive K+ Channel Opening Increased the Airway Smooth Muscle Cell Proliferation by Activating the PI3K/AKT Signaling Pathway in a Rat Model of Asthma 