Comparison of Clinical Features between the High and Low Serum KL-6 Patients with Acute Exacerbation of Interstitial Lung Diseases

Figure 3

Relationship between 6-month mortality and CCIS. In the patients with low serum KL-6 levels, the AUC is 0.836 in the evaluation of CCIS as a predictor of 6-month mortality (a). The optimal cutoff CCIS for estimating 6-month mortality is 4 points ( < 0.001). Log-rank tests show that the Kaplan–Meier survival curves of these groups differ significantly ( < 0.001) (A). On the contrary, in the patients with high serum KL-6 levels, the AUC value is 0.663 in the evaluation of CCIS as a predictor of 6-month mortality (b). Log-rank tests show that the Kaplan–Meier survival curves of these groups do not differ significantly ( = 0.083) (B). AUC: area under the ROC curve; CCIS: Charlson Comorbidity Index score; KL-6: Krebs von den Lungen-6.

(a)

(b)