Anti-Myxovirus Resistance Protein-1 Immunoglobulin A Autoantibody in Idiopathic Pulmonary Fibrosis

Table 5

Univariate and multivariate Cox proportional hazard regression analyses to evaluate prognostic factors.

Parameters	HR	95% CI	value
Univariate analysis
Gender, male vs. female	0.988	0.405–2.410	0.979
Age	1.023	0.977–1.072	0.328
Smoking, y/n	0.877	0.337–2.283	0.788
Diagnosis of IPF, clinical vs. SLB	1.474	0.732–2.967	0.277
BMI	0.957	0.855–1.071	0.444
mMRC, 2≤ vs. <2	4.946	2.411–10.021	<0.001
%FVC	0.950	0.930–0.970	<0.001
%DLco	0.961	0.939–0.983	0.001
Neutrophils in BAL, %	1.093	1.020–1.172	0.012
Lymphocytes in BAL, %	0.962	0.913–1.014	0.152
GAP stage, II vs. I	6.799	2.960–15.617	<0.001
GAP stage, III vs. I	11.055	2.113–57.840	0.004
KL-6, x100 U/mL	1.056	1.019–1.095	0.003
SP-D, x10 ng/mL	1.020	1.005–1.036	0.009
HRCT pattern
Possible UIP vs. UIP	1.006	0.476–2.129	0.987
Inconsistent with UIP vs. UIP	1.259	0.292–5.423	0.758
Multivariate analysis using background parameters except for GAP stage
mMRC, 2≤ vs. <2	2.923	1.366–6.251	0.006
%FVC	0.956	0.936–0.984	0.001

HR, hazard ratio; CI, confidence interval; IPF, idiopathic pulmonary fibrosis; BMI, body mass index; mMRC, modified Medical Research Council score for shortness of breath; %FVC, percent predicted value of forced vital capacity; %DLco, percent predicted value of diffusing capacity of carbon monoxide; GAP stage, gender, age, and physiology stage; KL-6, Krebs von den Lungen-6; SP-D, surfactant protein; HRCT, high-resolution computed tomography; UIP, usual interstitial pneumonia. Prognostic significance of each parameter was evaluated by univariate Cox proportional hazard regression analysis. Multivariate analysis with the stepwise method was performed using all significant parameters except for GAP stage to clarify prognostic factors specific for our cases other than GAP stage. HRs of %FVC and %DLco less than 1 suggest patients with higher %FVC and higher %DLco survive longer.