Research Article

Clinical Manifestations of Pulmonary Mucormycosis in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A 21-Case Series Report and Literature Review

Table 2

Differences between survivors and nonsurvivors within 100 days.

VariableValue, n (%) value
Patient survivedPatient deceased

Gender (male)9 (81.8%)10 (100%)0.262
Age42.0 ± 10.344.5 ± 14.80.572
DM2 (18.2%)4 (40.0%)0.268
Coinfection
 CMV4 (36.4%%)3 (30.0%)0.562
 Bacteria5 (45.5%)5 (50.0%)0.590
 Leukemia relapse3 (27.3%)1 (10.0%)0.331
 GVHD2 (18.2%)6 (60.0%)0.063
 Hemoptysis4 (36.4%)9 (90.0%)0.017a
 WBC2.4 (1.6–3.2)1.3 (0.1–3.3)0.307
 NE0.9 (0.4–1.9)0.7 (0.08–1.4)0.647
 CRP196.5 ± 92.5255.7 ± 115.30.291
 Multilobar8 (72.7%)9 (100%)0.145
 Cavitary infiltrate6 (54.5%)4 (44.4%)0.500
 Reversed halo sign3 (27.3%)3 (33.3%)0.574
 Pleural effusion5 (45.5%)5 (55.6%)0.500
 Pneumothorax1 (9.1%)0 (0.0%)0.550
Rhizopus7 (77.8%)5 (50.0%)0.220
 Extrapulmonary involvementb4 (36.4%)2 (20.0%)0.367
 Surgery2 (18.2%)0 (0%)0.262

a value is statistically significant. bWhen the observation time was extended to 365 days, no extrapulmonary involvement occurred in the survival group and all patients with extrapulmonary involvement died within 1 year. CMV: cytomegalovirus; NE: neutrophils.