The Neutrophil-to-Lymphocyte Ratio is Associated with the Requirement and the Duration of Invasive Mechanical Ventilation in Acute Respiratory Distress Syndrome Patients: A Retrospective Study
Table 1
Comparisons of baseline characteristics between the nonmechanical ventilation group and the invasive mechanical ventilation group.
Variables
Non-MV group (n = 185)
IMV group (n = 193)
value
Age (years)
66 (52–76)
67 (51–75)
0.929
Male, n (%)
119 (64.3)
147 (76.2)
0.012
Smoking, n (%)
54 (29.2)
48 (24.9)
0.344
Alcohol abuse, n (%)
29 (15.7)
39 (20.2)
0.252
Hypertension, n (%)
47 (25.4)
57 (29.5)
0.369
Diabetes mellitus, n (%)
49 (26.5)
44 (22.8)
0.405
Coronary artery disease, n (%)
22 (11.9)
20 (10.4)
0.636
Risk factor, n (%)
0.646
Pneumonia
122 (65.9)
130 (67.4)
Aspiration
7 (3.8)
12 (6.2)
Sepsis
15 (8.1)
13 (6.7)
Others
41 (22.2)
38 (19.7)
Types of infection, n (%)
0.665
Bacteria
151 (81.6)
154 (79.8)
Virus
11 (5.9)
8 (4.1)
Fungus
6 (3.3)
9 (4.7)
Unknown
17 (9.2)
22 (11.4)
PaO2/FiO2 (mmHg)
200 (160–236.5)
126 (82.94–184.62)
<0.001
Categories of ARDS, n (%)
<0.001
Mild
87 (47.0)
36 (18.7)
Moderate
79 (42.7)
81 (41.9)
Severe
19 (10.3)
76 (39.4)
WBC, 109/L
9.22 (6–11.46)
9.8 (7.02–11.84)
0.249
Hb, g/L
118.48 ± 25.49
106.29 ± 25.81
<0.001
RDW, %
13.7 (13–15.1)
13.9 (13.1–15)
0.519
Hematocrit
0.35 ± 0.08
0.33 ± 0.09
0.010
Platelets, 109/L
178.37 (127–261)
161.5 (93–229)
0.013
Lactate, mmol/L
2 (1.25–3.37)
2.54 (1.4–4.46)
0.017
Alb, g/L
31.58 ± 6.25
30.35 ± 7.02
0.073
MLR
0.51 (0.32–0.80)
0.59 (0.30–0.93)
0.147
NLR
10.36 (4.99–15.88)
14.95 (7.73–27.99)
<0.001
AST
39.45 (21.25–107.53)
47.6 (24.68–107.75)
0.204
ALT
38.45 (20–103.38)
45.7 (20.08–107.4)
0.566
Cr, μmol/L
103.07 (54.9–183)
84.5 (56.35–174.25)
0.962
BUN, mmol/L
9.1 (5.36–15.73)
11 (7–17.05)
0.011
APACHE II score
12 (8–15)
13 (9–17)
0.078
SOFA score
7 (5–8)
8 (6–10)
<0.001
Intervention (1st24 h), n (%)
Steroida
91 (49.2)
115 (59.6)
0.042
Alimentotherapy
92 (49.7)
112 (58.0)
0.106
Vasoactive drugsb
27 (14.6)
87 (45.1)
<0.001
CRRT
20 (10.8)
34 (17.6)
0.059
Outcomes
28-day mortality, n (%)
40 (21.6)
73 (37.8)
0.001
Hospital length of stay
14 (9–20)
18 (11–26)
0.002
aSteroid therapy was defined as at least a dose (≥0.5 mg/kg) of methylprednisolone. bVasoactive drugs include epinephrine, norepinephrine, vasopressin, dobutamine, dopamine, and phenylephrine. MV, mechanical ventilation; IMV, invasive mechanical ventilation; WBC, white blood cell; Hb, hemoglobin; RDW, red cell distribution width; Alb, albumin; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Cr, creatinine; BUN, blood urea nitrogen; APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; CRRT, continuous renal replacement therapy.
