The Neutrophil-to-Lymphocyte Ratio is Associated with the Requirement and the Duration of Invasive Mechanical Ventilation in Acute Respiratory Distress Syndrome Patients: A Retrospective Study
Table 2
Comparisons of baseline characteristics between the noninvasive ventilation group and the invasive mechanical ventilation group.
Variables
NIV group (n = 142)
IMV group (n = 193)
value
Age (years)
68 (60–77)
67 (51–75)
0.134
Male, n (%)
97 (68.3)
147 (76.2)
0.110
Smoking, n (%)
39 (27.5)
48 (24.9)
0.593
Alcohol abuse, n (%)
31 (21.8)
39 (20.2)
0.718
Hypertension, n (%)
39 (27.5)
57 (29.5)
0.679
Diabetes mellitus, n (%)
34 (23.9)
44 (22.8)
0.806
Coronary artery disease, n (%)
17 (12.0)
20 (10.4)
0.642
Risk factor, n (%)
0.008
Pneumonia
118 (83.1)
130 (67.4)
Aspiration
4 (2.8)
12 (6.2)
Sepsis
8 (5.6)
13 (6.7)
Others
12 (8.5)
38 (19.7)
Types of infection, n (%)
0.795
Bacteria
115 (80.9)
154 (79.8)
Virus
4 (2.9)
8 (4.1)
Fungus
9 (6.3)
9 (4.7)
Unknown
14 (9.9)
22 (11.4)
PaO2/FiO2 (mmHg)
139 (100–193.68)
126 (82.94–184.62)
0.040
Categories of ARDS, n (%)
0.036
Mild
30 (21.1)
36 (18.7)
Moderate
75 (52.8)
81 (41.9)
Severe
37 (26.1)
76 (39.4)
WBC, 109/L
9.62 (7.73–11.44)
9.8 (7.02–11.84)
0.549
Hb, g/L
106.58 ± 23.78
106.29 ± 25.81
0.919
RDW, %
13.8 (12.9–15.3)
13.9 (13.1–15)
0.786
Hematocrit
0.33 ± 0.08
0.33 ± 0.09
0.535
Platelets, 109/L
155.5 (123.12–228)
161.5 (93–229)
0.413
Lactate, mmol/L
2.31 (1.4–3.46)
2.54 (1.4–4.46)
0.293
Alb, g/L
32.02 ± 6.42
30.35 ± 7.02
0.026
MLR
0.63 (0.33–1.08)
0.59 (0.30–0.93)
0.229
NLR
10.66 (6.56–17.80)
14.95 (7.73–27.99)
0.001
AST
52 (25.3–120)
47.6 (24.68–107.75)
0.525
ALT
34.7 (17.8–84.5)
45.7 (20.08–107.4)
0.220
Cr, μmol/L
105.15 (62.32–186.12)
84.5 (56.35–174.25)
0.423
BUN, mmol/L
11.25 (7.07–17.76)
11 (7–17.05)
0.872
APACHE II score
12 (9–15)
13 (9–17)
0.112
SOFA score
7 (6–9)
8 (6–10)
0.022
Intervention (1st24 h), n (%)
Steroida
82 (57.7)
115 (59.6)
0.735
Alimentotherapy
73 (51.4)
112 (58.0)
0.228
Vasoactive drugsb
40 (28.2)
87 (45.1)
0.002
CRRT
21 (14.8)
34 (17.6)
0.490
Outcomes
28-day mortality, n (%)
37 (26.1)
73 (37.8)
0.023
Hospital length of stay
14 (9–22)
18 (11–26)
0.013
aSteroid therapy was defined as at least a dose (≥0.5 mg/kg) of methylprednisolone. bVasoactive drugs include epinephrine, norepinephrine, vasopressin, dobutamine, dopamine, and phenylephrine. NIV, noninvasive ventilation; IMV, invasive mechanical ventilation; WBC, white blood cell; Hb, hemoglobin; RDW, red cell distribution width; Alb, albumin; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Cr, creatinine; BUN, blood urea nitrogen; APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; CRRT, continuous renal replacement therapy.
