Canadian Respiratory Journal

Research Article

The Neutrophil-to-Lymphocyte Ratio is Associated with the Requirement and the Duration of Invasive Mechanical Ventilation in Acute Respiratory Distress Syndrome Patients: A Retrospective Study

Table 3

Influence factors for requirement of IMV in ARDS patients by univariate and multivariate logistic regression analysis.


Variables	Univariate analysis		Multivariate analysis
Variables	OR (95% CI)	value	OR (95% CI)	value

Male, n (%)	1.642 (1.098–2.456)	0.016
PaO₂/FiO₂ (mmHg)	0.991 (0.988–0.994)	<0.001	0.993 (0.989–0.996)	<0.001
Hb, g/L	0.989 (0.982–0.996)	0.003	0.989 (0.981–0.998)	0.012
Hematocrit	0.106 (0.012–0.960)	0.046
Platelets, 10⁹/L	0.998 (0.996–1.000)	0.061
Lactate, mmol/L	1.166 (1.075–1.263)	<0.001	1.160 (1.063–1.265)	0.001
Alb, g/L	0.968 (0.942–0.994)	0.018
NLR	1.046 (1.031–1.062)	<0.001	1.042 (1.025–1.060)	<0.001
APACHE II score	1.043 (1.009–1.078)	0.012
SOFA score	1.137 (1.073–1.205)	<0.001
Alimentotherapy	1.358 (0.948–1.943)	0.095
Vasoactive drugs^b	3.185 (2.155–4.707)	<0.001	2.504 (1.601–3.917)	<0.001

^bVasoactive drugs include epinephrine, norepinephrine, vasopressin, dobutamine, dopamine, and phenylephrine. IMV, invasive mechanical ventilation; ARDS, acute respiratory distress syndrome; Hb, hemoglobin; Alb, albumin; NLR, neutrophil-to-lymphocyte ratio; APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; OR, odds ratio; CI, confidence interval.