The Neutrophil-to-Lymphocyte Ratio is Associated with the Requirement and the Duration of Invasive Mechanical Ventilation in Acute Respiratory Distress Syndrome Patients: A Retrospective Study
Table 5
Baseline characteristics of IMV group in different NLR levels.
Variables
Low NLR (NLR ≤14.95, n = 97)
High NLR (NLR >14.95, n = 96)
value
Age (years)
63 (47–73)
71 (56–77)
0.002
Male, n (%)
77 (79.4)
70 (72.9)
0.292
Smoking, n (%)
29 (29.9)
19 (19.8)
0.104
Alcohol abuse, n (%)
26 (26.8)
13 (13.5)
0.022
Hypertension, n (%)
25 (25.8)
32 (33.3)
0.250
Diabetes mellitus, n (%)
17 (17.5)
27 (28.1)
0.079
Coronary artery disease, n (%)
13 (13.4)
7 (7.3)
0.164
Risk factor, n (%)
0.414
Pneumonia
60 (61.9)
70 (72.9)
Aspiration
7 (7.2)
5 (5.2)
Sepsis
7 (7.2)
6 (6.3)
Others
23 (23.7)
15 (15.6)
Types of infection, n (%)
0.432
Bacteria
82 (84.5)
72 (75.0)
Virus
3 (3.1)
5 (5.2)
Fungus
3 (3.1)
6 (6.3)
Unknown
9 (9.3)
13 (13.5)
PaO2/FiO2 (mmHg)
140 (89.17–219.84)
115 (81.53–166.83)
0.024
Categories of ARDS, n (%)
0.005
Mild
27 (27.8)
9 (9.4)
Moderate
36 (37.1)
45 (46.9)
Severe
34 (35.1)
42 (43.8)
WBC, 109/L
9.69 (5.95–12.13)
9.57 (6.95–11.62)
0.947
Hb, g/L
104.43 ± 27.59
108.18 ± 23.88
0.313
RDW, %
14.05 (13–15.18)
13.7 (13.2–14.8)
0.551
Hematocrit
0.33 ± 0.09
0.33 ± 0.08
0.862
Platelets, 109/L
168.43 ± 105.87
172.20 ± 99.18
0.799
Lactate, mmol/L
2.39 (1.28–4.90)
2.61 (1.5–4.22)
0.864
Alb, g/L
33 (27.5–36.77)
28.4 (23.2–32.4)
<0.001
MLR
0.39 (0.25–0.64)
0.79 (0.48–1.37)
<0.001
NLR
7.79 (3.78–10.80)
27.99 (20.15–47.36)
<0.001
AST
46 (23.4–138)
48 (27.2–86.6)
0.877
ALT
43.6 (20–107.2)
49 (20.4–108)
0.984
Cr, μmol/L
80.3 (52–164.28)
88.85 (60.55–183.91)
0.217
BUN, mmol/L
10.11 (6.71–16.02)
11.83 (6.96–19.28)
0.158
APACHE II score
12 (8–16)
14 (9–18)
0.283
SOFA score
8 (6–10)
8 (6–10)
0.885
Interventions, n (%)
Steroida
57 (58.8)
58 (60.4)
0.815
Alimentotherapy
52 (53.6)
60 (62.5)
0.211
Vasoactive drugsb
41 (42.3)
46 (47.9)
0.430
CRRT
16 (16.5)
18 (18.8)
0.681
28-day mortality, n (%)
29 (29.9)
44 (45.8)
0.022
Duration of ventilation
8 (3–13)
10 (6–16)
0.025
Hospital length of stay
16 (8–25)
18 (12–26)
0.173
aSteroid therapy was defined as at least a dose (≥0.5 mg/kg) of methylprednisolone. bVasoactive drugs include epinephrine, norepinephrine, vasopressin, dobutamine, dopamine, and phenylephrine. IMV, invasive mechanical ventilation; ARDS, acute respiratory distress syndrome; WBC, white blood cell; Hb, hemoglobin; RDW, red cell distribution width; Alb, albumin; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Cr, creatinine; BUN, blood urea nitrogen; APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; CRRT, continuous renal replacement therapy.
