Role of Neuron-Specific Enolase in the Diagnosis and Disease Monitoring of Sarcoidosis
Table 2
Diagnostic significance of ACE, sIL-2R, NSE, and the combination for sarcoidosis.
Parameter
No. of patients with sarcoidosis/nonsarcoidosis
value
Sensitivity (%)
Specificity (%)
PPV (%)
NPV (%)
ACE ()
46/0
<0.001
41.1
100
100
48.4
ACE ()
66/62
sIL-2R ()
85/26
<0.001
84.2
53.6
76.6
65.2
sIL-2R ()
16/30
NSE ()
57/16
0.001
50.9
74.2
78.1
45.5
NSE ()
55/46
ACE () and/or sIL-2R ()
86/26
<0.001
86.9
53.6
76.8
69.8
Double ()
13/30
ACE () and/or NSE ()
73/16
<0.001
66.4
74.2
82.0
55.4
Double ()
37/46
sIL-2R () and/or NSE ()
92/32
<0.001
92.9
42.9
74.2
77.4
Double ()
7/24
ACE () and/or sIL-2R () and/or NSE ()
91/32
<0.001
93.8
42.9
74.0
80.0
Triple ()
6/24
PPV: positive predictive value; NPV: negative predictive value. The data were obtained when cutoff values of ACE, sIL-2R. and NSE were 21.4 IU/L, 482 U/ml, and 12.0 ng/ml, respectively.
