SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis

<div>The analysis of the relative expression of Rev-Erb<i>α</i> activation by SR9009 and SR8278 in vitro. ELISA detection of proinflammatory cytokine production: (a) IL-6, (b) TNF-<i>α</i>, and (c) anti-inflammatory cytokine production IL-10 in RAW246.7 cells after treatment with DMSO (control group), LPS, SR9009, SR9009 + LPS, SR8278, and SR8278 + LPS; knock-down of Rev-Erb<i>α</i> in RAW246.7 cells aggravated the inflammatory response: (d) IL-6, (e) TNF-<i>α</i>, and (f) IL-10 in RAW246.7 cells. 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Canadian Respiratory Journal

SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis

Figure 3