The Value of Adenosine Deaminase 2 in the Detection of Tuberculous Pleural Effusion: A Meta-Analysis and Systematic Review

Table 1

A clinical summary of the included studies.

First author	Year	Country	Sample size	Aetiology of non-TPE	Gold standard	Testing method	Cutoff value (U/L)	TP	FP	FN	TN
Valdés [18]	1996	Spain	350	Malignant, parapneumonic, CHF, empyema, and others	Microbiology or biopsy	Giusti’s method	40	76	11	0	263
Gorguner [19]	2000	Turkey	87	Malignant and parapneumonic	Microbiology or biopsy	Giusti and Galanti’s method	29	33	4	3	47
GAO [20]	2005	China	190	Malignant	Clinical diagnosis	Muraoka’s method	37.8	119	4	22	45
Mohammadtaheri [21]	2005	IRAN	93	Malignant, parapneumonic, transudates, and others	Microbiology or biopsy	Giusti and Galanti’s method	42	30	7	1	55
Nella [22]	2009	India	34	Malignant	Microbiology or biopsy	Giusti and Galanti’s method	60	18	1	4	11
Zemlin [23]	2009	South Africa	879	Malignant, bacterial, empyema, transudates, and others	Microbiology or biopsy + clinical diagnosis	Giusti and Galanti’s method	40.6	355	30	10	484
Li [24]	2009	China	64	Malignant	Microbiology + clinical diagnosis	NA	19.7	30	1	6	27
Shi [25]	2011	Taiwan	155	Malignant, parapneumonic, CHF, and others	Microbiology or biopsy + antituberculosis treatment	NA	24	29	7	3	116
Keng [26]	2013	Taiwan	88	Malignant and others	Microbiology or biopsy + clinical diagnosis	Giusti and Galanti’s method	12	26	4	5	53
Li [27]	2014	China	90	Malignant	Microbiology or biopsy	Muraoka’s method	29.45	36	3	11	40
Yurt [28]	2014	Turkey	93	Malignant and others	Microbiology or biopsy	Giusti’s method	20.37	41	7	2	43
Wang [29]	2020	China	52	Malignant	Clinical diagnosis	Enzyme colorimetry	30.4	23	0	6	23
Zhang [30]	2020	China	155	Malignant, parapneumonic, CHF, and others	Microbiology or biopsy + antituberculosis treatment	Muraoka’s method	26	29	7	3	116

NA, not available; FN, false-negative; FP, false-positive; TN, true-negative; TP, true-positive; CHF, congestive heart failure.