Association of GSTM1 and GSTT1 Null Genotypes with Toluene Diisocyanate-Induced Asthma

Table 1

Clinical characteristics of the study subjects.

Variables	TDI-PA	TDI-NA	value
N	27	26	—
Age (years)	58.7 ± 8.6	57.1 ± 10.9	0.60
Sex (male, female)	23/4	21/5	0.72
Smoke (NS/ES/SM)	9/12/6	6/9/11	0.28
Atopy (Y, N)	19/8	15/11	0.39
FVC (% predicted)	87.48 ± 21.31	92.96 ± 12.62	0.26
FEV1 (% predicted)	90.22 ± 24.86	97 ± 13.07	0.22
FEV1_FVC (%)	76.22 ± 16.67	81.42 ± 9.06	0.16
Decline of FEV1 after the TDI challenge (%)	35.15 ± 15.13	4.57 ± 3.98	3.66E − 11
Serum total IgE (kU/I)	463.18 ± 689.94	154.23 ± 200.42	0.03

Numeric data are presented as mean ± standard deviation. TDI, toluene diisocyanate; TDI-PA, TDI-positive asthma; TDI-NA, TDI-negative asthma; ES, ex-smokers; NS, never smokers; SM, current smokers. values were obtained using the independent t-test or χ²-test and were considered significant when less than 0.05.