Canadian Respiratory Journal

Research Article

Association of GSTM1 and GSTT1 Null Genotypes with Toluene Diisocyanate-Induced Asthma

Table 3

Combined analysis of GSTM1 and GSTT1 mutant frequencies according to the response of the TDI challenge.
GenotypesTDI-PA (%)/TDI-NA (%)OR (95% CI) value
GSTM1 wild/GSTT1 wild3 (11.1)/6 (23.0)1.0 (reference)—
GSTM1 null/GSTT1 wild8 (29.6)/9 (34.6)1.77 (0.33–9.55)0.50
GSTM1 wild/GSTT1 null3 (11.1)/7 (26.9)0.85 (0.12–5.94)0.87
GSTM1 null/GSTT1 null13 (48.2)/4 (15.3)6.50 (1.09–38.63)0.04
TDI-PA: TDI challenge positive asthma and TDI-NA: TDI challenge negative asthma. values were obtained using logistic regression analysis and were considered significant when less than 0.05.