Total (n ) Impaired diffusing capacity diagnosed by DLCO Impaired diffusing capacity diagnosed by DLCO/VA Decreased VA ≥80% prediction <80% prediction ≥80% prediction <80% prediction ≥80% prediction <80% prediction Number 175 94 81 134 41 85 90 Age (years) 175 (100%) 58.17 ± 12.53 66.84 ± 11.68 <0.001 60.66 ± 12.59 67.17 ± 12.61 0.004 58.62 ± 13.43 65.54 ± 11.39 <0.001 Sex, male 106 (60.5%) 53 (56.4%) 53 (65.4%) 0.22 77 (57.5%) 29 (70.7%) 0.128 41 (48.2%) 65 (72.2%) 0.001 Hemoglobin (g/L) 175 (100%) 133.17 ± 17.36 125.99 ± 16.84 0.006 131.29 ± 12.60 135.10 ± 12.61 0.047 129.98 ± 17.12 129.69.10 ± 17.83 0.914 Duration of disease (years) 175 (100%) 0.84 (0.00, 5.00) 6.00 (1.75, 10.00) <0.001 2.00 (0, 6.00) 10.00 (5.00, 12.50) <0.001 2.00 (0, 7.00) 5.00 (0, 10.00) 0.006 Modified Reiff score 175 (100%) 5.00 (3.00, 8.00) 8.00 (5.00, 12.00) <0.001 6.00 (4.00, 9.25) 8.00 (4.00, 12.00) 0.037 5.00 (3.00, 8.00) 8.00 (5.00, 11.00) <0.001 Frequency of hospitalization in the last 2 years 175 (100%) 1.00 (1.00, 1.00) 1.00 (1.00, 2.00) 0.02 1.00 (1.00, 1.00) 2.00 (1.00, 2.00) <0.001 1.00 (1.00, 1.00) 2.00 (1.00, 2.00) 0.108 Frequency of exacerbation in the last 2 years 175 (100%) 1.00 (1.00, 2.00) 2.00 (1.00, 3.00) <0.001 1.00 (1.00, 2.00) 3.00 (1.50, 3.00) <0.001 1.00 (1.00, 2.00) 2.00 (1.00, 3.00) 0.083 Body mass index (kg/m2 ) <18.5 34 (19.4%) 9 (9.6%) 25 (30.9%) <0.001 19 (14.2%) 15 (36.6%) 0.003 11 (12.9%) 23 (25.6%) 0.031 18.5∼24 85 (48.6%) 43 (45.7%) 42 (51.9%) 66 (49.3%) 19 (46.3%) 40 (47.1%) 45 (50.0%) ≥24 56 (32.0%) 42 (44.7%) 14 (17.3%) 49 (36.6%) 7 (17.1%) 34 (40.0%) 22 (24.4%) Smoking status Smoker or ex-smoker 77 (44.0%) 32 (34.0%) 45 (55.6%) 0.005 53 (39.6%) 24 (58.5%) 0.032 28 (32.9%) 49 (54.4%) 0.004 Nonsmoker 98 (56.0%) 62 (66.0%) 37 (44.4%) 81 (60.4%) 17 (41.5%) 57 (67.1%) 41 (45.6%) Pseudomonas aeruginosa colonization Yes 12 (6.9%) 3 (3.2%) 9 (11.1%) 0.04 8 (6.0%) 4 (9.8%) 0.627 4 (4.7%) 8 (8.9%) 0.274 No 163 (93.2%) 91 (96.8%) 72 (88.9%) 126 (94.0%) 37 (90.2%) 81 (95.3%) 82 (91, 1%) Lower airway pathogen detection None 122 (69.7%) 72 (76.6%) 50 (61.7%) 0.08 97 (72.4%) 25 (61.0%) 0.212 64 (75.3%) 58 (64.4%) 0.187 Pseudomonas aeruginosa 22 (12.61%) 8 (8.5%) 14 (17.3%) 17 (12.7%) 5 (12.2%) 7 (8.2%) 15 (16.7%) Other pathogen 31 (18.9%) 14 (14.9%) 17 (21.0%) 20 (14.9%) 11 (26.8%) 14 (16.5%) 17 (18.9%) Chronic obstructive pulmonary disease Yes 64 (36.6%) 20 (21.3%) 44 (54.3%) <0.001 35 (26.1%) 29 (70.7%) <0.001 23 (27.1%) 41 (45.6%) 0.011 No 111 (63.4%) 74 (78.7%) 37 (45.7%) 99 (73.9%) 12 (29.3%) 62 (72.9%) 49 (54.4%) Asthma Yes 20 (11.4%) 16 (17.0%) 4 (4.9%) 0.01 18 (13.4%) 2 (4.9%) 0.220 13 (15.3%) 7 (7.8%) 0.118 No 155 (88.6%) 78 (83.0%) 77 (95.1%) 116 (86.6%) 39 (95.1%) 72 (84.7%) 83 (92.2%) Interstitial lung disease Yes 13 (7.4%) 1 (7.7%) 12 (92.3%) 0.001 8 (6.0%) 5 (12.2%) 0.322 4 (4.7%) 9 (10.0%) 0.182 No 162 (92.6%) 93 (57.4%) 69 (42.6%) 126 (94.0%) 36 (87.8%) 81 (95.3%) 81 (90.0%) Pulmonary arterial hypertension Yes 27 (15.4%) 4 (4.3%) 23 (28.4%) 0.001 8 (6.0%) 5 (12.2%) <0.001 8 (9.4%) 19 (21.1%) 0.032 No 148 (84.6%) 90 (95.7%) 58 (71.6%) 126 (94.0%) 36 (87.8%) 77 (90.6%) 71 (78.9%) Cardiovascular diseases Yes 56 (32.0%) 23 (25.3%) 33 (40.7%) 0.02 38 (28.4%) 18 (43.9%) 0.062 25 (29.4%) 31 (34.4%) 0.476 No 119 (68.0%) 71 (74.7%) 48 (59.3%) 96 (71.6%) 23 (56.1%) 60 (70.6%) 59 (65.6%) Diabetes mellitus Yes 20 (11.4%) 12 (12.8%) 8 (9.9%) 0.55 16 (11.9%) 4 (9.8%) 0.917 11 (12.9%) 9 (10.0%) 0.541 No 155 (88.6%) 82 (87.2%) 73 (90.1%) 118 (88.1%) 37 (90.2%) 74 (87.1%) 81 (90.0%) Gastroesophageal reflux disease Yes 21 (12.0%) 12 (12.8%) 9 (11.1%) 0.74 17 (12.7%) 4 (9.8%) 0.818 7 (8.2%) 14 (15.6%) 0.136 No 154 (88.0%) 82 (87.2%) 72 (88.9%) 117 (87.3%) 37 (90.2%) 78 (91.8%) 76 (84.4%) Other complications Yes 85 (48.6%) 48 (51.1%) 37 (45.7%) 0.48 65 (48.5%) 20 (48.8%) 0.976 41 (48.2%) 44 (48.9%) 0.931 No 90 (51.4%) 46 (48.9%) 44 (54.3%) 69 (51.5%) 21 (51.2%) 44 (51.8%) 46 (51.1%) Bronchi cystic dilation Yes 92 (52.6%) 43 (45.7%) 49 (60.5%) 0.05 67 (50.0%) 25 (61.0%) 0.218 40 (47.1%) 52 (57.8%) 0.156 No 83 (47.4%) 51 (54.3%) 32 (39.5%) 67 (50.0%) 16 (39.0%) 45 (52.9%) 38 (42.2%) Bronchi varicose dilation Yes 110 (62.9%) 55 (58.5%) 55 (67.9%) 0.20 83 (61.9%) 27 (65.9%) 0.650 52 (61.2%) 58 (64.4%) 0.655 No 65 (37.1%) 39 (41.5%) 26 (32.1%) 51 (38.1%) 14 (34.1%) 33 (38.8%) 32 (35.6%) Bronchi column dilation Yes 122 (69.7%) 65 (69.1%) 57 (70.4%) 0.86 92 (68.7%) 30 (73.2%) 0.582 59 (69.4%) 63 (70.0%) 0.933 No 53 (30.3%) 29 (30.9%) 25 (29.7%) 42 (31.3%) 11 (26.8%) 26 (30.6%) 27 (30.0%)
