Dexmedetomidine Attenuates LPS-Stimulated Alveolar Type II Cells’ Injury through Upregulation of miR-140-3p and Partial Suppression of PD-L1 Involving Inactivating JNK-Bnip3 Pathway

Figure 4

Effects of PD-L1 suppressing on JNK-Bnip3 pathway. (a) qPCR detected the relative expression of PD-L1 in RLE-6TN cells transfected with PD-L1 siRNAs. (b) Western blot detected the relative expression of PD-L1 in RLE-6TN cells transfected with PD-L1 siRNAs. (c) The relative expression of JNK, p-JNK, and Bnip3. (d) The levels of TNF-α, IL-6, and IL-8 in RLE-6TN cells. Data are presented as means ± SD (n = 3; , ).

(a)

(b)

(c)

(d)