Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis

<div>The schematic diagram of bleomycin infusion protocols in sheep (<i>n</i> = 8) and mouse (<i>n</i> = 14) models. (a) In individual sheep (<i>n</i> = 8), the left caudal lung segment received infusions of bleomycin, while the right caudal lung segment received the saline for controls. These infusions were repeated on day 14, and tissue samples were harvested on day 28. (b) For mice, there were two groups: one group of 7 animals (<i>n</i> = 7) received bleomycin intranasally, and for controls, another group of 7 (<i>n</i> = 7) received saline intranasally. These applications were repeated on day 7, and tissue samples were harvested on day 21. All the animals were kept for a 14-day resting period (pretreatment) prior to bleomycin administration.</div>

Canadian Respiratory Journal

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Figure 1

Figure 1: Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis 