Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis

<div>Fibrotic scores, fibrotic fractions, and tissue fractions of sheep (<i>n</i> = 8) and mouse (<i>n</i> = 14) lung tissues administered with either saline (control) or bleomycin (treatment). (a) H&amp;E staining was used to evaluate the fibrotic score and tissue fraction. (b) Masson’s trichrome staining was used to evaluate the % of blue staining. Ten representative randomly selected areas from each lung tissue sections were captured under ×20 magnification for the analysis. Fibrotic scores (c) were expressed as a median and interquartile range while fibrotic fraction (d) and tissue fraction (e) were expressed as means and standard errors of means. 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Canadian Respiratory Journal

fig2

Figure 2

Figure 2: Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis 