Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis

<div>Tertiary lymphoid aggregates in the parenchyma of sheep lung segments exposed to bleomycin. The top two panels show serial sections immuno-stained with either a Pax-5 primary antibody to identify B-cells or a CD-3 antibody to identify T-cells (a) (40x). The graph shows the number of tertiary lymphoid aggregates in the lung parenchyma of saline and bleomycin-infused lung segments of sheep (<i>n</i> = 8) (b). Note that zero lymphoid aggregates were found in saline control lung segments (<i>n</i> = 8). Each bar represents the mean ± standard error of the mean. 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Canadian Respiratory Journal

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Figure 6

Figure 6: Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis 