Research Article
High-Flow Nasal Cannula versus Noninvasive Ventilation in AECOPD Patients with Respiratory Acidosis: A Retrospective Propensity Score-Matched Study
Table 6
Univariate logistic regression analysis of factors related to HFNC failure.
| | Variable | Univariate analysis | | OR (95% CI) | value |
| | Gender | 1.429 (0.374–5.459) | 0.602 | | Age (years) | 1.077 (0.989–1.174) | 0.088 | | Body mass index | 1.084 (0.975–1.205) | 0.135 | | Charlson | 1.362 (0.979–1.895) | 0.103 | | Home NIV use | 9.231 (0.939–90.781) | 0.057 | | Body temperature (°C) | 1.816 (0.477–6.915) | 0.382 | | Hear rate (beats/min) | 0.987 (0.942–1.033) | 0.567 | | Respiratory rate (breaths/min) | 1.095 (0.943–1.270) | 0.233 | | Mean arterial pressure (mmHg) | 0.958 (0.906–1.013) | 0.129 | | APACHE II | 1.064 (0.903–1.253) | 0.459 | | GCS | 0.001 (0) | 0.999 | | SAPS II | 1.114 (0.982–1.264) | 0.102 | | White blood cell (109) | 0.940 (0.821–1.077) | 0.375 | | Neutrophil (%) | 0.977 (0.916–1.043) | 0.489 | | CRP (mg/L) | 0.925 (0.691–1.238) | 0.599 | | PCT (μg/L) | 0.933 (0.645–1.350) | 0.713 | | Log NT-proBNP (pg/dl) | 7.506 (1.746–32.263) | 0.007 | | Creatinine (μmol/L) | 1.012 (0.997–1.027) | 0.128 | | CCR (mL/min) | 0.996 (0.963–1.031) | 0.835 | | Albumin (g/L) | 0.950 (0.840–1.075) | 0.417 | | LVEF (%) | 1.104 (0.965–1.264) | 0.148 | | RVSP (mmHg) | 0.966 (0.967–1.027) | 0.808 | | pH on admission | 0.001 (0.000–20.933) | 0.170 | | PaCO2 on admission | 1.021 (0.989–1.053) | 0.201 | | PaO2 on admission | 0.991 (0.969–1.013) | 0.409 | | PaO2/FIO2 on admission | 0.988 (0.975–1.002) | 0.101 | | Pneumonia | 0.893 (0.193–4.134) | 0.885 | | Cor pulmonale | 1.019 (0.278–3.737) | 0.978 | | Heart failure | 3.611 (0.739–17.644) | 0.113 | | Hypertension | 0.391 (0.112–1.361) | 0.140 | | Coronary artery disease | 2.167 (0.526–8.926) | 0.284 | | Old myocardial infarction | 1.429 (0.374–5.459) | 0.602 | | Atrial fibrillation | 1.077 (0.989–1.174) | 0.088 | | OSAHS | 4.000 (0.335–47.726) | 0.273 | | Diabetes mellitus | 9.231 (0.939–90.781) | 0.057 |
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APACHE, Acute Physiology and Chronic Health Evaluation; CCR, creatinine clearance rate; CRP, C-reactive protein; GCS, Glasgow Coma Scale; HFNC, high-flow nasal cannula; ICU, intensive care unit; LVEF, left ventricular ejection fraction; Log NT-proBNP, log-transformed N-terminal pro-brain natriuretic peptide; OSAHS, obstructive sleep apnea and hypoventilation syndrome; PCT, procalcitonin; RVSP, right ventricular systolic pressure; SAPS, Simplified Acute Physiology Score.
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