Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence?

Table 1

Summary of experimental evidence for antioxidant vitamins in AF prevention.

Study	Model	Setting	Intervention/groups	Results	Relevance to AF
Carnes et al. 2001 [15]	Instrumented dogs—atrial electrodes	External ATP	Ascorbic acid versus control	Attenuated shortening of ERP	Prevention
Shiroshita Takeshita et al. 2004 [28]	Dogs—atrial electrodes	External ATP	control versus simvastatin versus vitamin C versus vitamin C & E	Vitamin C/E had no effect	No effect
Lin YK et al. 2010 [41]	Isolated rabbit PVs and LA tissues	In vitro hydrogen peroxide oxidation treatment	Ascorbic acid versus control	Reduced PV spontaneous activity and abolished burst PV firing	Prevention

ATP: atrial tachypacing; ERP: effective refractory period; LA: left atrium; PV: pulmonary vein.