Research Article
Genetic Variants Are Not Rare in ICD Candidates with Dilated Cardiomyopathy: Time for Next-Generation Sequencing?
Table 4
Patients’ characteristics according to molecular study results.
| | Patient characteristics | No variant () | Variant-positive () | value |
| | Age at dx, years (mean ± SD) | 40 ± 11 | 42 ± 14 | 0.633 | | Age at ICD implantation, years (mean ± SD) | 50 ± 12 | 51 ± 13 | 0.872 | | Male, (%) | 9 (60) | 3 (50) | 1.000 | | Familial cases, (%) | 6 (40) | 3 (50) | 1.000 | | Family history, (%) | | | | | Sudden cardiac death | 1 (7) | 2 (33) | 0.184 | | Previous hospitalizations, (%) | 9 (64) | 4 (67) | 1.000 | | Heart failure-related | 8 (57) | 2 (33) | 0.628 | | Arrhythmic causes | 4 (29) | 3 (50) | 0.613 | | NYHA, (%) | | | | | >I | 10 (67) | 5 (83) | 0.802 | | ECG data, (%) | | | | | LBBB | 7 (47) | 3 (50) | 1.000 | | Atrial fibrillation | 3 (20) | 1 (17) | 1.000 | | NSVT | 4 (36) | 2 (33) | 1.000 | | PVC | 5 (33) | 0 (0) | 0.262 | | Echocardiogram data | | | | | LVEDD (mm) (mean ± SD) | 65 ± 7 | 63 ± 6 | 0.503 | | LVEF (%) (mean ± SD) | 24 ± 8 | 34 ± 7 | 0.024 | | RV impairment, (%) | 4 (31) | 3 (50) | 0.617 |
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ICD: implantable cardioverter defibrillator; LBBB: left bundle branch block; LVEDD: left ventricular end-diastolic diameter; LVEF: left ventricular ejection fraction; NSVT: nonsustained ventricular tachycardia; RV: right ventricle; SD: standard deviation.
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