The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase

<div>Correlation analysis of MPO activity with vascular endothelial function, NOx content, and cGMP level in thoracic aorta rings between HC diet rats and after intervention with the PPARγ agonist. There was a positive correlation between MPO activity and the log EC50 value of ACh-induced vasodilation (a); ACh-induced maximum vasodilatation (b), NOx content (c), and cGMP level (d) showed negative correlation with MPO activity.</div>

Cardiology Research and Practice

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Figure 4: The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase

Figure 4 | The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase 