Review Article

Beta Blocker Therapy in Heart Failure Patients with Active Cocaine Use: A Systematic Review

Table 1

Characteristics of studies examining the effect of beta blockers in heart failure patients with active cocaine use.

SourceArticle typeStudy typeNo. of patientsAge group (years) of casesHeart failure categoryBeta blocker class

Ahmed et al. [10]Meeting abstractRetrospective cohort (2008)326Not specifiedNot specifiedNot specified
Finks et al. [11]Conference abstractCase control (72 months)76Not specifiedHFrEFCombined α and β blocker (carvedilol) and other β blockers (not specified)
Littmann et al. [12]Letter to the editorCase series451–57HFrEFCombined α and β blocker (carvedilol)
Akpa et al. [13]Conference abstractCase control (2006–2008)132Not specifiedHFrEFCardioselective and noncardioselective (not specified)
Ocal et al. [14]Case studyCase report134HFrEFCombined α and β blocker (carvedilol)
Finks et al. [15]Conference abstractCase control (72 months)21757.3 (SD 4.8)HFrEFCombined α and β blocker (carvedilol)
Nguyen et al. [16]Original study publicationRetrospective cohort (1993–2012)26755.5 (SD 7.51)Not specified (LVEF <45%)Cardioselective (bisoprolol, metoprolol) and noncardioselective (carvedilol, labetalol)
Egbuche et al. [17]Meeting abstractRetrospective cohort9056.1(SD 7.8)HFrEFNot specified
Lopez et al. [18]Original study publicationRetrospective cohort (01/2010–06/2016)3854 (SD 8.4)HFrEFCombined α and β blocker (carvedilol) and cardioselective β blocker (metoprolol)
Egbuche et al. [19]Original study publicationRetrospective cohort (2011–2014)26854.1 (SD 7)HFrEFCombined α and β blocker (carvedilol), cardioselective β blocker (metoprolol), and mixed type
Lopez et al. [20]Original study publicationRetrospective cohort7254 (SD 8.4)HFrEFCombined α and β blocker (carvedilol) and cardioselective β blocker (metoprolol)
Alvi et al. [21]Meeting abstractRetrospective cohort503Not specifiedHFrEF, HFbEF, and HFpEFCombined α and β blocker (carvedilol)

HFrEF, heart failure with reduced ejection fraction; HFbEF, heart failure with borderline ejection fraction; HFpEF, heart failure with preserved ejection fraction; LVEF, left ventricular ejection fraction; SD, standard deviation.