Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice

Figure 4

(a) Left ventricular remodeling (LVR) as assessed by cardiac MRI. Daily oral administration of ALA initiated 1 day post-AMI significantly reduced left ventricular end-systolic volume (LVESV) relative to controls, both at 28 and 56 days post-AMI ( vs. control at either time point). (b) Left ventricular function as assessed by cardiac MRI. Daily oral administration of ALA initiated 1 d post-AMI significantly preserved left ventricular ejection fraction (LVEF) relative to controls, both at day 28 and 56 days post-AMI (: vs. H₂O-treated group at either time point).

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