Low Levels of MicroRNA-10a in Cardiovascular Endothelium and Blood Serum Are Related to Human Atherosclerotic Disease

Figure 1

miR-10a is highly expressed in the EC layer of human nondiseased arteries but is decreased in atherosclerotic coronary arteries. Cross-section samples of coronary arteries with advanced atherosclerotic lesion (advan. lesion) vs. coronary arteries with minimal atherosclerotic lesion (mini. lesion) or nondiseased internal thoracic aorta (CL artery) were stained with human miR-10a and vWF (i.e., EC marker) and counterstained with DAPI. vWF was used to identify the endothelium of blood vessels. Arrow, vWF-positive ECs; IEL, internal elastic lamina; L, lumen; EC, endothelial cell; CL artery, control artery.