Low Levels of MicroRNA-10a in Cardiovascular Endothelium and Blood Serum Are Related to Human Atherosclerotic Disease

Figure 2

GATA6 (direct target of miR-10a) in the endothelium is highly expressed in human atherosclerotic coronary arteries in vivo. Cross-sections of diseased human arteries vs. nondiseased human arteries, i.e., coronary arteries with advan. lesions vs. coronary arteries with mini. lesions or CL arteries, were immunohistochemically stained to detect inflammatory transcriptional factor GATA6 and vWF and counterstained with DAPI. vWF was used to identify the endothelium of blood vessels. Arrow, vWF-positive endothelial cells; IEL, internal elastic lamina; L lumen; CL artery, control artery.