Low Levels of MicroRNA-10a in Cardiovascular Endothelium and Blood Serum Are Related to Human Atherosclerotic Disease

Figure 3

miR-10a downstream VCAM-1 in the endothelium is upregulated in human atherosclerotic coronary arteries in vivo. Cross-sections of diseased coronary arteries with advan. lesions vs. coronary arteries with mini. lesions or CL arteries were immunohistochemically stained for the inflammatory molecule VCAM-1 and vWF and counterstained with DAPI. vWF was used to identify the endothelium of blood vessels. Arrow, vWF-positive endothelial cells; IEL, internal elastic lamina; L lumen; CL artery, control artery.