Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia
Table 1
Characteristics of patients at baseline.
Characteristics
All patients (n = 91)
NT-proBNP <300 pg/ml (n = 68)
NT-proBNP ≥300 pg/ml (n = 23)
value
Age, years
61.0 (47.0–69.0)
54.5 (41.5–67.0)
68.0 (66.0–75.0)
<0.001
Male, n (%)
39 (43.011)
27 (39.7)
12 (52.2)
0.296
Coexisting illnesses
Hypertension, n (%)
19 (20.9)
8 (11.8)
11 (47.8)
<0.001
Diabetes, n (%)
4 (4.4)
3 (4.4)
1 (4.3)
1.000
Ischemic heart disease, n (%)
1 (1.0)
1 (1.5)
0 (0.0)
1.000
Chronic obstructive pulmonary disease, n (%)
7 (7.7)
3 (4.4)
4 (17.4)
0.043
Cancer
3 (3.3)
1 (1.5)
2 (8.7)
0.156
Vital signs
Temperature, °C
36.5 (36.4–36.7)
36.5 (36.4–36.7)
36.6 (36.4–36.7)
0.712
Respiratory rate, per min
20.0 (18.0–21.3)
20.0 (18.0–21.0)
20.0 (18.0–22.0)
0.323
Heart rate, beats per min
86.5 (78.0–98.0)
88.0 (78.0–98.0)
82.0 (76.0–98.0)
0.289
Systolic blood pressure, mmHg
128.5 (120.0–140.0)
125.0 (119.0–135.0)
135.0 (125.0–47.0)
0.034
Diastolic blood pressure, mmHg
78.0 (73.5–84.5)
77.0 (73.0–83.0)
80.0 (75.0–90.0)
0.211
Laboratory findings
White cell count, per mm3
5300 (4000–6700)
4945 (3773–6180)
6200 (5280–7390)
0.003
Hemoglobin, g/liter
125.0 (114.0–137.0)
124.5 (114.0–35.5)
128.0 (114.0–137.0)
0.654
Hematocrit
0.36 (0.33–0.39)
0.36 (0.32–0.39)
0.37 (0.33–0.39)
0.638
Platelet count, per mm3
222,000 (122,000–282,000)
227,000 (170,000–284,500)
199,000 (132,000–273,000)
0.300
D-dimer
0.70 (0.35–1.83)
0.47 (0.37–1.45)
1.79 (0.83–8.88)
<0.001
CD4+ cell
444 (258–586)
468 (303–610)
275 (143–521)
0.018
CD8+ cell
244 (156–378)
252 (167–405)
216 (93–340)
0.149
Creatinine, μmol/liter
59.0 (48.0–71.0)
57.0 (48.0–69.8)
66.0 (49.0–76.0)
0.113
Alanine aminotransferase, U/liter
22.0 (15.0–39.0)
20.0 (14.3–35.8)
27.0 (18.0–44.0)
0.038
Aspartate aminotransferase, U/liter
24.0 (18.0–34.0)
22.0 (17.0–30.8)
33.0 (24.0–44.0)
0.004
Albumin, g/liter
37.8 (34.4–41.3)
38.3 (36.0–41.6)
35.7 (31.9–37.5)
0.005
Sodium, mEq/L
142 (138–145)
142.0 (139.0–145.0)
143.0 (37.0–145.0)
0.916
Procalcitonin, ng/mL
0.04 (0.03–0.07)
0.04 (0.03–0.06)
0.07 (0.03–0.14)
0.074
C-reactive protein, mg/liter
11.2 (5.0–46.8)
8.1 (5.0–38.8)
55.0 (5.6–169.5)
0.005
Creative kinase MB, U/liter
1.0 (0.6–1.5)
0.92 (0.58–1.35)
1.16 (0.94–1.98)
0.002
hs-cTnI > 99th percentile URL
10 (11.1)
3 (4.4)
7 (30.4)
0.002
NT-proBNP, pg/ml
91.2 (30.0–305.4)
49.8 (23.1–28.1)
437.7 (346.7–808.1)
<0.001
Radiographic finding
More than two lobes involvement
76 (98.7)
56 (98.2)
20 (100.0)
1.00
Pleural effusion
3 (3.9)
0 (0.0)
3 (15.0)
0.016
Ground-glass opacity
74 (96.1)
55 (96.5)
19 (95.0)
1.00
Consolidation
56 (72.7)
40 (70.2)
16 (80.0)
0.396
Fibrosis
48 (62.3)
30 (52.6)
18 (90.0)
0.003
CT score
8.0 (6.0–13.0)
7.0 (5.0–10.5)
14.0 (8.3–19.0)
<0.001
Pneumonia severity index (PSI)
Class I
26 (28.6)
26 (38.2)
0 (0.0)
<0.001
Class II
43 (47.3)
33 (48.5)
10 (43.5)
Classes III–V
22 (24.2)
9 (13.2)
13 (56.5)
Total point score for PSI class > I
66.0 (56.0–77.5)
61.0 (54.0–70.0)
73.0 (63.0–87.0)
0.005
Note. Data are expressed as median (interquartile range) or counts and percentage, as appropriate. hs-cTnI: high-sensitivity cardiac troponin I; URL: upper reference limit; NT-proBNP: N-terminal pro-B-type natriuretic peptide; CT: computed tomography.
