TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation

<div>Exos-related genes in hepatocytes were dysregulated by TMAO. (a) A total of 101 genes related to Exos changed significantly (<svg height="8.68572pt" id="M4" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> &lt; 0.05) after TMAO treatment. (b) The differentially expressed genes were significantly enriched in the biological processes of secretion, peptide metabolic process, export from the cell, membrane fusion, and small-molecule biosynthetic process. (c) Phgdh, Mdh2, Echs1, Rap2a, Gpd1l, Slc3a2, Hyou1, Hspa9, Psat1, and Pck2 were identified as the top 10 hub genes.</div>

Cardiology Research and Practice

fig1

Figure 1

Figure 1: TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation 