TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation

Figure 4

Exos were widely distributed in vivo with different patterns. Exos secreted by TMAO-treated hepatocytes could be efficiently captured by (a) cardiomyocytes, (b) hepatocytes, and (c) endothelial cells in the aorta. (d) The Exos appeared to keep themselves out of the skeletal muscle cells and preferentially located in the endothelial cells.

(a)

(b)

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(d)