Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris

Table 3

Major adverse cardiac and cerebral events in patients with UAP in the β-blocker and no β-blocker groups.

	Before PS match			After PS match
	β-Blocker (-) N = 1801	β-Blocker (+) N = 3790	value	β-Blocker (-) N = 1786	β-Blocker (+) N = 1786	value
Event
Composite MACCE
No. of patients	420	1005		417	463
Event rate (%)	23.3	26.5	0.010	23.3	25.9	0.074
Unadjusted HR (95% CI)	1.00	1.08 (0.96, 1.21)	0.212	1.00	1.04 (0.91, 1.19)	0.545
Adjusted HR (95% CI)	1.00	0.98 (0.87, 1.10)	0.725	1.00	0.98 (0.86, 1.13)	0.812
All-cause death
No. of patients	49	142		49	70
Event rate (%)	2.7	3.7	0.048	2.7	3.9	0.050
Unadjusted HR (95% CI)	1.00	1.29 (0.93, 1.78)	0.129	1.00	1.34 (0.93, 1.93)	0.114
Adjusted HR (95% CI)	1.00	1.05 (0.75, 1.47)	0.769	1.00	1.30 (0.90, 1.89)	0.163
Cardiac death
No. of patients	17	53		17	26
Event rate (%)	0.9	1.4	0.153	1.0	1.5	0.167
Unadjusted HR (95% CI)	1.00	1.38 (0.80, 2.38)	0.248	1.00	1.43 (0.78, 2.63)	0.253
Adjusted HR (95% CI)	1.00	0.98 (0.56, 1.71)	0.930	1.00	1.27 (0.68, 2.39)	0.454
Nonfatal MI
No. of patients	32	72		32	35
Event rate (%)	1.8	1.9	0.751	1.8	2.0	0.711
Unadjusted HR (95% CI)	1.00	1.01 (0.67, 1.53)	0.958	1.00	1.04 (0.65, 1.69)	0.864
Adjusted HR (95% CI)	1.00	0.88 (0.57, 1.35)	0.558	1.00	1.06 (0.65, 1.72)	0.814
Nonfatal stroke
No. of patients	14	41		14	17
Event rate (%)	0.8	1.1	0.281	0.8	1.0	0.588
Unadjusted HR (95% CI)	1.00	1.28 (0.70, 2.35)	0.423	1.00	1.12 (0.55, 2.27)	0.757
Adjusted HR (95% CI)	1.00	1.04 (0.56, 1.94)	0.891	1.00	1.13 (0.56, 2.31)	0.732
Heart failure
No. of patients	25	82		18	29
Event rate (%)	1.4	2.2	0.048	1.0	1.6	0.106
Unadjusted HR (95% CI)	1.00	1.48 (0.95, 2.32)	0.085	1.00	1.55 (0.56, 2.78)	0.147
Adjusted HR (95% CI)	1.00	1.20 (0.78, 1.89)	0.445	1.00	1.28 (0.71, 2.32)	0.409
Cardiac rehospitalization
No. of patients	375	874		372	400
Event rate (%)	20.8	23.1	0.060	20.8	22.4	0.255
Unadjusted HR (95% CI)	1.00	1.05 (0.93, 1.18)	0.456	1.00	1.02 (0.88, 1.17)	0.803
Adjusted HR (95% CI)	1.00	0.96 (0.85, 1.09)	0.554	1.00	0.99 (0.86, 1.14)	0.889

Data are presented as number or HR (95% CI). MACCE, major adverse cardiac and cerebral events; MI, myocardial infarction.