Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris

Table 5

Multivariate Cox regression analysis of secondary endpoints.

	Univariate		Multivariate
	HR (95% CI)	value	A		B		C
			HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value
Age (years)	1.07 (1.06, 1.08)	<0.001	1.07 (1.05, 1.08)	<0.001	1.05 (1.04, 1.07)	<0.001	1.05 (1.04, 1.06)	<0.001
Male (%)	0.89 (0.68, 1.09)	0.205
Stroke (%)	1.86 (1.43, 2.43)	<0.001	1.44 (1.10, 1.88)	0.008	1.38 (1.09, 1.76)	0.008	1.3861.08, 1.70)	0.009
Heart rate (bpm)	1.02 (1.01, 1.03)	<0.001	1.02 (1.01, 1.03)	<0.001	1.01 (1.00, 1.02)	0.002	1.01 (1.00, 1.02)	<0.001
hsCRP (mg/L)	1.03 (1.02, 1.05)	<0.001	1.02 (1.00, 1.03)	0.027	1.02 (1.00, 1.03)	0.034	1.02 (1.00, 1.03)	0.026
HbA1C (%)	1.14 (1.06, 1.23)	<0.001	1.09 (1.01, 1.19)	0.032	1.15 (1.07, 1.23)	<0.001	1.15 (1.07, 1.22)	<0.001
LVEF ≥ 50%	Ref		Ref		Ref		Ref
40% ≤ LVEF < 50%	2.63 (1.67, 4.15)	<0.001	1.94 (1.21, 3.10)	0.006	1.69 (1.10, 2.61)	0.017	1.78 (1.19, 2.66)	0.005
LVEF < 40%	6.41 (3.92, 10.49)	<0.001	6.24 (3.76, 10.35)	<0.001	4.42 (2.69, 7.29)	<0.001	4.25 (2.65, 6.81)	<0.001
LM (%)	2.06 (1.53, 2.78)	<0.001	1.47 (1.08, 2.00)	0.016	1.39 (1.06, 1.84)	0.019
Multivessels (%)	3.58 (2.19, 5.85)	<0.001	2.47 (1.50, 4.08)	<0.001	2.30 (1.51, 3.52)	<0.001	2.28 (1.56, 3.37)	<0.001
CTO (%)	2.03 (1.50, 2.76)	<0.001
β-Blockers at discharge (%)	1.41 (1.07, 1.85)	0.013

A, present all-cause death/HF; B, present all-cause death/HF/nonfatal MI; C, present all-cause death/HF/nonfatal MI/nonfatal stroke. MI, myocardial infarction; HbA_IC, glycosylated hemoglobin; hsCRP, hypersensitivity C-reactive protein; LVEF, left ventricular ejection fraction; LM, left main trunk; CTO, chronic total occlusions.