Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Group Format in Spain: Results of a Noninferiority Randomized Controlled Trial at 15 Months after Treatment Onset
Table 4
Main effects of the linear mixed models across condition and different treatment periods ().
Main effects
Dependent variable
T1
T2
T3
T4
T5
Cohen’s
(SD)
(SD)
(SD)
(SD)
(SD)
T1 to T2
T2 to T3
T3 to T4
T4 to T5
T1 to T5
Primary outcomes
BDI-II
UP
29.00 (12.09)
20.37 (14.02)
18.44 (14.09)
17.55 (14.83)
16.48 (12.81)
76.98
≤0.001
0.67
0.14
0.06
0.08
1.01
TAU
28.68 (12.26)
22.15 (12.63)
21.46 (13.95)
18.64 (13.93)
19.37 (14.96)
42.24
≤0.001
0.53
0.05
0.20
0.05
0.72
ODSIS
UP
10.58 (4.98)
6.67 (5.62)
6.01 (5.76)
6.02 (6.25)
5.72 (5.48)
61.04
≤0.001
0.75
0.12
≤0.001
0.05
0.93
TAU
9.79 (5.48)
8.03 (5.70)
7.64 (5.76)
7.11 (5.34)
6.83 (6.03)
14.81
≤0.001
0.32
0.07
0.09
0.05
0.53
BAI
UP
28.06 (13.14)
20.92 (14.12)
18.61 (14.41)
17.56 (14.71)
17.09 (13.91)
52.77
≤0.001
0.53
0.16
0.07
0.03
0.81
TAU
27.24 (13.30)
22.99 (14.24)
22.05 (14.26)
20.16 (14.15)
19.48 (14.85)
21.28
≤0.001
0.31
0.07
0.13
0.05
0.57
OASIS
UP
11.27 (4.27)
7.58 (5.02)
6.77 (5.28)
6.55 (5.67)
6.30 (5.29)
67.58
≤0.001
0.81
0.16
0.04
0.04
1.03
TAU
10.73 (4.58)
8.70 (4.94)
8.66 (5.13)
8.13 (5.03)
7.41 (5.59)
20.70
≤0.001
0.43
0.01
0.10
0.14
0.69
Secondary outcomes
Neuroticism
UP
33.24 (7.05)
30.05 (7.89)
28.21 (9.03)
27.08 (9.28)
26.69 (8.39)
41.35
≤0.001
0.43
0.22
0.12
0.04
0.84
TAU
32.42 (7.57)
30.35 (7.90)
29.58 (7.81)
28.58 (7.77)
27.20 (8.00)
16.28
≤0.001
0.27
0.10
0.13
0.17
0.68
Negative affect
UP
29.55 (8.42)
24.49 (8.67)
24.25 (8.38)
22.48 (9.16)
22.10 (8.31)
29.01
≤0.001
0.59
0.03
0.20
0.04
0.89
TAU
29.52 (8.38)
25.95 (9.07)
22.3 (7.64)
23.94 (8.18)
24.40 (9.71)
24.34
≤0.001
0.41
0.43
-0.21
-0.05
0.59
Extraversion
UP
21.22 (8.30)
23.15 (8.87)
23.93 (9.12)
24.41 (9.32)
24.23 (8.76)
17.30
≤0.001
-0.23
-0.09
-0.05
0.02
-0.36
TAU
21.81 (8.42)
22.16 (8.55)
22.07 (8.44)
23.62 (8.34)
23.20 (8.70)
0.66
0.621
0.04
0.01
-0.18
0.05
-0.16
Positive affect
UP
20.54 (6.84)
23.34 (8.01)
24.25 (8.38)
24.64 (9.21)
26.21 (8.71)
21.42
≤0.001
-0.38
-0.11
-0.04
-0.17
-0.77
TAU
20.75 (7.02)
22.39 (7.16)
22.30 (7.64)
22.82 (7.77)
24.17 (8.33)
5.71
≤0.001
-0.23
0.01
-0.07
-0.17
-0.47
QLI
UP
4.40 (1.61)
5.38 (1.91)
5.63 (1.83)
5.96 (1.97)
5.97 (1.86)
57.48
≤0.001
-0.57
-0.13
-0.17
≤0.001
-0.93
TAU
4.54 (1.56)
5.10 (1.68)
5.24 (1.84)
5.45 (1.85)
5.68 (2.03)
18.88
≤0.001
-0.35
-0.08
-0.11
-0.12
-0.68
Note: UP: Unified Protocol; TAU: treatment as usual; BDI-II: Beck Depression Inventory; ODSIS: Overall Depression Severity and Impairment Scale; BAI: Beck Anxiety Inventory; OASIS: Overall Anxiety Severity and Impairment Scale; QLI: Quality of Life Index; T1: pretreatment; T2: 3 months after treatment onset; T3: 6 months after treatment onset; T4: 9 months after treatment onset; T5: 15 months after treatment onset. values < 0.05 are in bold.
