Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Group Format in Spain: Results of a Noninferiority Randomized Controlled Trial at 15 Months after Treatment Onset
Table 5
ANOVA between treatment conditions throughout the intervention with intention-to-treat participants and per-protocol noninferiority analysis.
Dependent variable
T1
T2
T3
T4
T5
Per-protocol non-inferiority analysis
T1 to T2
T1 to T5
Cohen’s
Cohen’s
Cohen’s
Cohen’s
Cohen’s
Primary outcomes
BDI-II
0.45
0.505
0.06
0.89
0.347
0.10
3.80
0.052
0.22
0.34
0.559
0.08
1.69
0.195
0.20
-2.13
0.017
-2.08
0.020
ODSIS
3.51
0.062
0.16
4.85
0.028
0.24
7.06
0.008
0.30
2.26
0.134
0.19
1.12
0.291
0.16
-5.54
≤0.001
-2.53
0.006
BAI
0.81
0.368
0.08
1.48
0.225
0.13
4.61
0.033
0.04
1.80
0.181
0.17
0.74
0.391
0.13
-2.73
0.003
-1.51
0.067
OASIS
3.60
0.058
0.16
3.55
0.060
0.20
10.50
≤0.001
0.37
5.06
0.025
0.29
0.97
0.326
0.15
-4.93
≤0.001
-2.40
0.009
Secondary outcomes
Neuroticism
2.28
0.132
0.13
0.01
0.937
0.01
1.63
0.203
0.15
1.04
0.309
0.13
0.02
0.897
0.02
-2.70
0.004
-1.29
0.100
Negative affect
0.32
0.571
0.05
1.10
0.294
0.11
6.48
0.011
0.29
1.01
0.315
0.13
1.59
0.210
0.19
-2.57
0.005
-1.07
0.143
Extraversion
0.89
0.346
0.08
0.72
0.397
0.09
3.08
0.080
0.20
0.36
0.550
0.08
0.31
0.578
0.08
2.88
0.002
3.00
0.002
Positive affect
0.18
0.669
0.04
0.71
0.401
0.09
3.02
0.084
0.20
2.34
0.127
0.20
2.34
0.128
0.23
1.98
0.024
3.24
≤0.001
QLI
1.60
0.207
0.11
1.19
0.276
0.12
4.81
0.029
0.25
4.23
0.041
0.27
0.83
0.364
0.14
2.41
0.008
1.29
0.100
Note: UP: Unified Protocol; TAU: treatment as usual; BDI-II: Beck Depression Inventory; ODSIS: Overall Depression Severity and Impairment Scale; BAI: Beck Anxiety Inventory; OASIS: Overall Anxiety Severity and Impairment Scale; QLI: Quality of Life Index; T1: pretreatment; T2: 3 months after treatment onset; T3: 6 months after treatment onset; T4: 9 months after treatment onset; T5: 15 months after treatment onset; : Welch’s -test. The value of is negative or positive when the test is applied to the lower bound or upper bound, respectively. values < 0.05 are in bold.
