Change in Negative Affective Bias following a Single Ketamine Treatment for Treatment-Resistant Depression

Table 2

Neurocognitive measures and outcomes.

Neurocognitive measures		Control	Midazolam	Ketamine	Time	Group
		M (SD)	M (SD)	M (SD)
SST %	Pre	9.1 (8.8)	36.8 (19.4)	50.1 (31.8)	.17	.93	.03
	Post	-	41.8 (20.9)	30.1 (26.9)
EST NEB (ms)	Pre	40.4 (105.2)	-51.3 (202.8)	41.9 (131.9)	.46	.20	.45
	Post	—	39.7 (174.6)	41.3 (100.5)
EST PEB Response time (ms)	Pre	9.1 (152.5)	-43.0 (165.8)	-0.69 (78.0)	.74	.22	.97
	Post	—	-33.6 (52.6)	10.6 (77.5)
AGNG Neg (ms)	Pre	524.6 (54.7)	542.9 (65.4)	500.4 (79.9)	.99	.28	.62
	Post	—	536.1 (63.4)	507.7 (105.3)
AGNG Pos (ms)	Pre	514.2 (56.6)	534.5 (56.6)	483.1 (67.5)	.23	.07	.96
	Post	—	545.6 (58.8)	495.0 (76.7)
Ruff 2 & 7 total speed T-score	Pre	50.3 (8.8)^b	44.00 (5.1)^a	49.6 (4.9)^c	.01	.08	.28
	Post	—	47.8 (6.4)^a	51.2 (5.5)^c
COWAT total correct	Pre	41.83 (11.1)	43.5 (9.6)^a	35.5 (6.6)	.04	.02	.25
	Post	—	48.3 (11.5)^a	36.9 (9.0)

Abbreviations: EST NEB: Emotional Stroop Task Negative Expressions Bias; EST PEB: Emotional Stroop Task Positive Expressions Bias; COWAT: Controlled Word Association Test; AGNG Neg: Affective Go/No Go Task Negative Shift; AGNG Pos: Affective Go/No Go Positive Shift; Ruff 2 & 7: Ruff 2 & 7 Selective Attention Test; SST: Scrambled Sentence Task; ^a; ^b, ^c; comparison between ketamine and midazolam groups.