Altered Reward Circuit Function Moderates the Relationship between Childhood Maltreatment and Depression Severity in Adolescents

<div>RSFC of left pGP and DMPFC as moderators of the relationship between traumatic experiences (including total CTQ score/childhood abuse) and AO-MDD severity. Separate lines for -0.5, 0, and +0.5 SD from the sample RSFC mean are for visualization purposes only. Abbreviations: HAMD-17: 17-item Hamilton Depression Rating Scale; CTQ: Childhood Trauma Questionnaire; RSFC: resting-state functional connectivity; pGP: posterior globus pallidus; DMPFC: dorsolateral prefrontal.</div>

Depression and Anxiety

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Figure 2: Altered Reward Circuit Function Moderates the Relationship between Childhood Maltreatment and Depression Severity in Adolescents 