Altered Reward Circuit Function Moderates the Relationship between Childhood Maltreatment and Depression Severity in Adolescents

Table 2

Multiple linear regression of HAMD-17 total by CTQ total and abuse and neglect with RSFC as a moderator.

	Estimate	SE
Model 1: CTQ total
Intercept	33.3208	6.6458	5.0138	<0.0001
Age	-0.0571	0.5117	-0.1116	0.9115
Education	-0.2300	0.5358	-0.4293	0.6692
Female sex	-2.1604	1.3715	-1.5752	0.1203
CTQ	-0.8725	1.8696	-0.4667	0.6424
RSFC	188.2752	84.5123	2.2278	0.0295
CTQ total × RSFC	-84.6361	37.5215	-2.2557	0.0276
Model 2:abuse
Intercept	30.7182	5.3559	5.7354	<0.0001
Age	0.0181	0.4875	0.0371	0.9706
Education	-0.2346	0.5130	-0.4573	0.6491
Female sex	-2.1657	1.3275	-1.6314	0.1079
Abuse	-0.1671	1.0686	-0.1564	0.8762
RSFC	163.0415	57.9125	2.8153	0.0065
Abuse × RSFC	-79.3071	27.6931	-2.8638	0.0057
Model 3:neglect
Intercept	33.2946	6.3723	5.2249	<0.0001
Age	0.1452	0.5395	0.2692	0.7887
Education	-0.4737	0.5585	-0.8481	0.3996
Female sex	-2.1326	1.4392	-1.4818	0.1435
Neglect	-1.1025	1.1927	-0.9243	0.3589
RSFC	72.8072	75.0155	0.9706	0.3355
Neglect × RSFC	-29.1675	29.1177	-1.0017	0.3204

Abbreviations: HAMD-17: 17-item Hamilton Depression Rating Scale; RSFC: resting-state functional connectivity.